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GenVoy-ILM™
Power to Explore
GenVoy-ILM, an off-the-shelf Research Use Only lipid nanoparticle reagent, lowers the barriers to developing genetic medicines
Explore Genetic Medicine with GenVoy-ILM
The RNA chemistry, the lipid composition and the manufacturing process affect characteristics of the resultant lipid nanoparticle.
GenVoy-ILM Demonstration on the NanoAssemblr® Ignite
Overview
GenVoy-ILM™ is an ionizable lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr®Platform. GenVoy-ILM is the simplest way to get started with LNPs - the most advanced non-viral technology for delivering nucleic acids.
An exclusive ionizable cationic lipid mix for preclinical development
With applications in Genetic Vaccine, Gene Therapy and Cell Therapy
For the treatment of cancer, rare disease, and infectious disease.
LNPs mimic low-density lipoproteins and are taken up through an endogenous pathway where they are designed to trigger the release of nucleic acids in the cytoplasm.
Deliver mRNA for Gene Expression
A single injection of GenVoy-ILM Factor VII siRNA-LNP was administered to mice via the tail vein at the RNA doses indicated and plasma levels of Factor VII protein were measured up to 21 days post-administration.
Lipid Nanoparticles
LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.
At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.
These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.
Learn More About Lipid Nanoparticles
Both The Chemistry And The Process Determine The Outcome
LNPs made with the NanoAssemblr®Platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing.
Use Genvoy-ILM for:
| Gene silencing | Gene editing |
| Gene expression | Gene modulation |
Use GenVoy-ILM to encapsulate and deliver:
| siRNA | gRNA |
| miRNA | mRNA |
| saRNA |
Product Information
GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.
2 mL, 5 mL
The Chemistry And The Process Affect The Outcome
LNPs made with the NanoAssemblr platform exhibit a unique homogeneous core structure with exceptionally consistent size within and between batches, which has been shown to be more potent than particles made by other methods.
Resource Center
Publication - Abstract
August 18, 2020
Nucleic Acids Research
Publication - Abstract
August 19, 2019
Journal of Liposome Research
Video
December 15, 2016
Publication - Abstract
August 03, 2020
Vaccines
Publication - Abstract
January 30, 2020
Advanced Materials
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