Power to Explore


GenVoy-ILM, an off-the-shelf Research Use Only lipid nanoparticle reagent, lowers the barriers to developing genetic medicines

Explore Genetic Medicine with GenVoy-ILM



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The RNA chemistry, the lipid composition and the manufacturing process affect characteristics of the resultant lipid nanoparticle.



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GenVoy-ILM Demonstration on the NanoAssemblr® Ignite

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GenVoy-ILM™ is an ionizable lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr®Platform.  GenVoy-ILM is the simplest way to get started with LNPs - the most advanced non-viral technology for delivering nucleic acids.



An exclusive ionizable cationic lipid mix for preclinical development


With applications in Genetic Vaccine, Gene Therapy and Cell Therapy


For the treatment of cancer, rare disease, and infectious disease.

LNPs mimic low-density lipoproteins and are taken up through an endogenous pathway where they are designed to trigger the release of nucleic acids in the cytoplasm.


Endogenous Uptake


Deliver mRNA for Gene Expression


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A single injection of GenVoy-ILM Factor VII siRNA-LNP was administered to mice via the tail vein at the RNA doses indicated and plasma levels of Factor VII protein were measured up to 21 days post-administration.

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Lipid Nanoparticles

LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.


At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.


These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.



Learn More About Lipid Nanoparticles

Nucleic Acid Lipid Nanoparticle


Both The Chemistry And The Process Determine The Outcome


LNPs made with the NanoAssemblr®Platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing. 

Use Genvoy-ILM for: 


Gene silencing Gene editing 
Gene expression Gene modulation 

Use GenVoy-ILM to encapsulate and deliver: 


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Product Information

GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.


2 mL, 5 mL

GenVoy-ILM Vials

The Chemistry And The Process Affect The Outcome 

LNPs made with the NanoAssemblr platform exhibit a unique homogeneous core structure with exceptionally consistent size within and between batches, which has been shown to be more potent than particles made by other methods. 



Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

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Resource Center


March 16, 2017

Targeted DNA Therapeutics - Challenges and Opportunities for Hepatic Diseases

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November 17, 2020

Closing Keynote: 2020 Nobel Prize laureate Dr Michael Houghton

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Publication - Abstract

May 13, 2021

Nature Communications

Tissue-specific Activation of Gene Expression by the Synergistic Activation Mediator (SAM) CRISPRa System in M...

C. Hunt, S.A. Hartford, G. Gong, et al

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Publication - Abstract

January 14, 2018

The Journal of Physical Chemistry

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectro...

J. Viger-Gravel, A. Schantz, A. Pinon, A. Rossini , S. Schantz and L. Emsley

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July 28, 2016

NanoAssemblr® GMP Scale-Up System | Ray Lockard, Precision NanoSystems

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Publication - Abstract

January 01, 2015

Journal of Nanomedicine and Nanotechnology

The Potential Use of Nanoparticles for Noggin siRNA Delivery to Accelerate Bone Formation in Distraction Osteo...

A.C.F. Bassit, P. Moffatt, M.H. Gaumond and R. Hamdy

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