The NanoAssemblr® commercial formulation system is an automated, single-use system for the clinical and commercial production of lipid nanoparticles under cGMP conditions, enabling efficient changeover and robust manufacturing processes.
The proprietary NxGen microfluidic mixer enables the reproducible scale-up of mRNA lipid nanoparticles by preserving the critical conditions at the point of formulation.
The NanoAssemblr Blaze from Precision NanoSystems is very good for the rapid scale-up of nanoparticle-based formulations. We were able to seamlessly transition our formulation developed on the NanoAssemblr Benchtop to the Blaze instrument and make large scale batches on the Blaze. The Blaze instrume...Read More
Senior Director, Head of Non-Viral Delivery
The scalability and reproducibility of PNI’s NanoAssemblr platform allowed us to move into GMP manufacturing with greater control over the process and increased precision in the final product compared to our previous macromixing process, allowing acceleration of our time to commercialization.
Chief Scientific Officer
In terms of ease of operation it almost doesn’t compare. The Ignite is really, really smooth. It genuinely takes about half the time to make the same subset of particles when we’re using the same machines (NABT and Ignite). It really does feel like the benchtop came out, it was out for a few years, ...Read More
Sr. Research Associate
Our team has been dedicated to developing safe and effective vaccines to fight against the COVID-19 pandemic. Since RNA vaccines are a disruptive technology as they do not require cell culture, utilize synthetic delivery and have a smaller manufacturing footprint, our partnership with PNI to advanc...Read More
Co-founder, Chairman and CEO
Ajinomoto Bio-Pharma Services has audited the PNI facilities in Vancouver and has qualified PNI's NanoAssemblr GMP System and its components. We are excited to work with PNI to offer their purpose-designed manufacturing technology and unique nanomedicine expertise to our clients for the manufacture ...Read More
Vice President and Head of US Operations
Ajinomoto Bio-Pharma Services
PNI is globally renowned for their NanoAssembr suite of products that enable high quality, consistent nanoparticle formation and seamless scale up from the laboratory to GMP manufacturing for the clinic. Using their GMP System will let us meet the challenge of producing our pan-coronavirus DNA vacci...Read More
Chief Executive Officer
eTheRNA used the NanoAssemblr® NxGen technology because we could perform precise tuning of the size of our nanoparticles to target the optimal immunogenicity in vivo.
Vice President of Manufacturing
Of particular note is LM03PE which had IgG levels of almost 108 ng/mL. We've never seen antibody levels this high.
Comments on PNI's proprietary RNA-LNP formulations eliciting a strong immune response in an influenza challenge study
Marie Skłodowska-Curie Research Fellow
Imperial College London
We look forward to working with Precision NanoSystems to support research efforts around the discovery of novel sLNPs that we believe have the potential to significantly improve and broaden biodistribution. sLNPs represent an exciting and innovative approach in Alnylam’s advancement of proprietary L...Read More
Chief Scientific Officer