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Proteins and Peptides
Proteins and peptides represent the second generation of therapeutic molecules. Being biological molecules, they have the ability to interact with other biological molecules to treat diseases such as cancer, autoimmunity, infectious diseases and more with improved specificity and targeting. Delivery technologies have not kept pace with the discovery of new protein drugs so there remain many challenges in formulating therapeutic proteins.
Researchers are encapsulating proteins and peptides into nanoparticles to:
• Improve solubility
• Control aggregation and concentration
• Control release
• Reformulate for different routes of administration
Proteins can be encapsulated into several types of nanoparticles including:
Liposomes
Polymer NPs and Micelles
Emulsions
LNPs
There are several published examples of using NanoAssemblr®
| Formulation Type | Protein Class | Related Resources |
| Proteo-liposome | Transmembrane Protein | Publication |
| Virosome | Viral Envelope Protein | Publication |
In addition to delivering the therapeutic peptide or protein itself, many researchers are encoding therapeutic proteins and peptides in mRNA or DNA and delivering those using nucleic acid LNPs to use the patient’s cellular machinery to produce the therapeutic.
Related Resources
Publication - Abstract
April 02, 2020
Journal of Controlled Release
Publication - Abstract
December 31, 2019
Vaccines
Publication - Summary
February 27, 2018
Cell Reports
Publication - Abstract
September 15, 2021
Vaccine
Publication - Abstract
August 11, 2021
Advanced Science
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