October 08, 2016
A wide range of studies have shown that liposomes can act as suitable adjuvants for a range of vaccine antigens. Properties such as their amphiphilic character and biphasic nature allow them to incorporate antigens within the lipid bilayer, on the surface, or encapsulated within the inner core. However, appropriate methods for the manufacture of liposomes are limited and this has resulted in issues with cost, supply, and wider scale application of these systems. Within this chapter we explore manufacturing processes that can be used for the production of liposomal adjuvants, and we outline new manufacturing methods can that offer fast, scalable, and cost-effective production of liposomal adjuvants.
Publication - Abstract
Aug 29, 2017
Journal of Liposome Research
Understanding the effect of liposome size on tendency for accumulation in tumor tissue requires preparation of defined populations of different sized particles. However, controlling the size distributions without changing the lipid composition is d...
Publication - Abstract
Jun 19, 2019
Dalton Transactions