Mastering the Tools: Natural versus Artificial Vesicles in Nanomedicine


Authors: L. Leggio, G. Arrabito, V. Ferrara, S. Vivarelli, G. Paterno, B. Marchetti, B. Pignataro and N. Iraci

Journal: Advanced Healthcare Materials

DOI: 10.1002/adhm.202000731

Publication - Abstract

August 31, 2020

Genetic Medicine

Abstract

Naturally occurring extracellular vesicles and artificially made
vesicles represent important tools in nanomedicine for the efficient delivery of
biomolecules and drugs. Since its first appearance in the literature 50 years
ago, the research on vesicles is progressing at a fast pace, with the main goal
of developing carriers able to protect cargoes from degradation, as well as to
deliver them in a time- and space-controlled fashion. While natural occurring
vesicles have the advantage of being fully compatible with their host, artificial
vesicles can be easily synthetized and functionalized according to the target to
reach. Research is striving to merge the advantages of natural and artificial
vesicles, in order to provide a new generation of highly performing vesicles,
which would improve the therapeutic index of transported molecules. This
progress report summarizes current manufacturing techniques used to
produce both natural and artificial vesicles, exploring the promises and pitfalls
of the different production processes. Finally, pros and cons of natural versus
artificial vesicles are discussed and compared, with special regard toward the
current applications of both kinds of vesicles in the healthcare field.

limit search to this category
Advanced Search

Advanced Search

close
  • Publications
  • Application Notes
  • Posters
  • Workshops
  • Videos & Webinars
  • Articles
Search

Browse by Category

  • Application
    • Diagnostic and Imaging
    • Genetic Medicine
    • Hematology
    • Metabolic Disorders
    • Neuroscience
    • Oncology
    • Skeletal Disorders
    • Targeted Drug Delivery
    • Vaccines
    • Other Applications
    • Cell therapy
  • Formulation
    • Liposomes
    • Nucleic Acid Lipid Nanoparticles
    • Polymeric Nanoparticles
    • Other Formulations
  • Payload
    • DNA
    • microRNA
    • mRNA
    • siRNA
    • Small Molecule Drugs
    • Other Payloads


related content

Publication - Summary

Mar 01, 2017
Neuro-Oncology

Immune Modulatory Nanoparticle Therapeutics for Intracerebral Glioma

N.K. Yaghi, J. Wei, Y. Hashimoto, L.Y. Kong, A.B Heimberger et al.

Hematology microRNA Genetic Medicine
Small interfering RNAs (siRNA) and microRNAs (miRNA) have gained a lot of clinical interest in recent years as they can specifically target genes/ proteins of interest and can be engineered to fit the patients’ unique needs and conditions.
Read More


Publication - Summary

Feb 24, 2015
American Chemical Society Nano

Localized RNAi Therapeutics of Chemoresistant Grade IV Glioma Using Hyaluronan-Grafted Lipid-Based Nanoparticles

Z.R. Cohen, S. Ramishetti, N. Peshes-Yaloz, M. Goldsmith, A. Wohl, Z. Zibly and D. Peer

siRNA Targeted Drug Delivery Oncology

Glioblastoma multiform (GBM) is one of the most malignant forms of brain tumors with very few treatment options other than aggressive surgical removal and radiotherapy. While most conventional chemotherapeutics fail when it comes to GBM, it is anti...

Read More


Sign Up and Stay Informed
Sign up today to automatically receive new Precision NanoSystems application notes, conference posters, relevant science publications, and webinar invites.
Sign Up