Advances in Development of mRNA-Based Therapeutics


Authors: L. Huang, L. Zhang, W. Li, S. Li, J. Wen, H. Li and Z. Liu

Journal: Current Topics in Microbiology and Immunology

DOI: https://doi.org/10.1007/82_2020_222

Publication - Abstract

July 19, 2020

Other Applications Nucleic Acid Lipid Nanoparticles Polymeric Nanoparticles
Recently, mRNA-based therapeutics have been greatly boosted since the development of novel technologies of both mRNA synthesis and delivery system. Promising results were showed in both preclinical and clinical studies in the field of cancer vaccine, tumor immunotherapy, infectious disease prevention and protein replacement therapy. Recent advancements in clinical trials also encouraged scientists to attempt new applications of mRNA therapy such as gene editing and cell programming. These studies bring mRNA therapeutics closer to real-world application. Herein, we provide an overview of recent advances in mRNA-based therapeutics.

limit search to this category
Advanced Search

Advanced Search

close
  • Publications
  • Application Notes
  • Posters
  • Workshops
  • Videos & Webinars
  • Articles
Search

Browse by Category

  • Application
    • Diagnostic and Imaging
    • Genetic Medicine
    • Hematology
    • Metabolic Disorders
    • Neuroscience
    • Oncology
    • Skeletal Disorders
    • Targeted Drug Delivery
    • Vaccines
    • Other Applications
    • Cell therapy
  • Formulation
    • Liposomes
    • Nucleic Acid Lipid Nanoparticles
    • Polymeric Nanoparticles
    • Other Formulations
  • Payload
    • DNA
    • microRNA
    • mRNA
    • siRNA
    • Small Molecule Drugs
    • Other Payloads


related content

Publication - Abstract

Nov 10, 2019
Journal of Controlled Release

Leukocyte-specific siRNA Delivery Revealing IRF8 as a Potential Anti-inflammatory Target

N. Veiga, M. Goldsmith, Y. Diesendruck, S. Ramishetti, D. Rosenblum, E. Elinav, M.A. Behlke, I. Benhar, and D. Peer

Nucleic Acid Lipid Nanoparticles mRNA
Interferon regulatory factor 8 (IRF8) protein plays a critical role in the differentiation, polarization, and activation of mononuclear phagocytic cells. In light of previous studies, we explored the therapeutic potential of IRF8 inhibition as immunomodulatory therapy for inflamm...
Read More


Publication - Summary

Dec 03, 2013
Molecular Therapy—Nucleic Acids

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

R.L. Rungta, H.B. Choi, P.J. Lin, R.W. Ko, D. Ashby, J. Nair, M. Manoharan, P.R. Cullis and B.A. MacVicar

siRNA Nucleic Acid Lipid Nanoparticles Neuroscience

The ability to manipulate gene expression and regulation in neurons is an invaluable asset to advancement of neuroscience and developing therapeutics for neurological disorders. 

Read More


Sign Up and Stay Informed
Sign up today to automatically receive new Precision NanoSystems application notes, conference posters, relevant science publications, and webinar invites.
Sign Up