Displaying results for your search.
Publication - Abstract
Sep 09, 2021
Signal Transduction and Targeted Therapy
Publication - Abstract
Aug 15, 2021
Analytical Biochemistry
Publication - Abstract
Aug 11, 2021
Advanced Science
Publication - Abstract
May 13, 2021
Nature Communications
Publication - Abstract
Apr 13, 2021
Pharmaceutics
Publication - Abstract
Mar 23, 2021
ACS Nano
Publication - Abstract
Mar 18, 2021
European Journal of Pharmaceutics and Biopharmaceutics
Use of the frit-inlet channel improves MD-AF4 analysis of LNP-RNA.
A robust method for AF4 separation of LNP-RNA has been developed and tested on two different platform.
The method meets all the ISO stan...
Publication - Abstract
Mar 18, 2021
Molecular Therapy
Publication - Abstract
Mar 13, 2021
Molecular Therapy Nucleic Acids
Publication - Abstract
Mar 12, 2021
Pharmaceutics
Publication - Abstract
Feb 25, 2021
Molecular Cancer
Publication - Abstract
Feb 16, 2021
Communications Biology
Publication - Abstract
Feb 11, 2021
Nano Letters
Publication - Abstract
Jan 28, 2021
Vaccines
Publication - Abstract
Jan 22, 2021
ACS Nano
Publication - Abstract
Dec 21, 2020
Molecular Therapy
Publication - Abstract
Nov 26, 2020
Journal of Controlled Release
mRNA was formulated in lipoplexes with ionizable, cationic or zwitterionic complexing lipids.
Cell populations in human skin were analyzed for RNA uptake and expression over 72 h.
Adipocytes exhibit...
Publication - Abstract
Nov 18, 2020
Science Advances
Publication - Abstract
Nov 18, 2020
Science Advances
Publication - Abstract
Nov 15, 2020
pharmaceutics
Publication - Abstract
Sep 29, 2020
Nature Communications
Publication - Abstract
Sep 25, 2020
ACS Applied Nano Materials
Publication - Abstract
Aug 21, 2020
Science Advances
Publication - Abstract
Aug 11, 2020
Journal of Controlled Release
siRNA and mRNA structures were separated from the ChriST mRNA by RNase H-mediated cleavage of RNA/DNA ...
Publication - Abstract
Jul 19, 2020
Current Topics in Microbiology and Immunology
Publication - Abstract
Jul 03, 2020
Journal of Medical Virology
Publication - Abstract
Jul 01, 2020
Journal of Controlled Release
Publication - Abstract
Jun 23, 2020
Advanced Functional Materials
Publication - Abstract
Jun 20, 2020
Advanced Drug Delivery Reviews
Publication - Abstract
Jun 08, 2020
Advanced Drug Delivery Reviews
Publication - Abstract
Jun 07, 2020
Pharmaceutics
Publication - Abstract
Jun 04, 2020
Nano Letters
Publication - Abstract
May 26, 2020
Cellular and Molecular Bioengineering
Lipid based nanoparticles (LNPs) are clinically successful vectors for hepatic delivery of nucleic acids. These systems are being developed for non-hepatic delivery of mRNA for the treatment of diseases like cystic fibrosis or retinal degeneration as well as infectious disease...
Publication - Abstract
May 08, 2020
Vaccines
Publication - Abstract
May 06, 2020
Nano Letters
Publication - Abstract
Apr 13, 2020
Advanced Drug Delivery Reviews
Publication - Abstract
Mar 11, 2020
Nano Letters
Publication - Abstract
Mar 10, 2020
ACS Chemical Biology
Publication - Abstract
Feb 20, 2020
Nature Communications
Publication - Abstract
Feb 04, 2020
npj Vaccines
Publication - Abstract
Nov 30, 2019
Journal of Controlled Release
Publication - Abstract
Nov 10, 2019
Journal of Controlled Release
Publication - Abstract
Sep 24, 2019
Nature Communications
Publication - Abstract
Aug 19, 2019
Journal of Liposome Research
Publication - Abstract
Aug 05, 2019
Molecular Therapy
Publication - Abstract
May 31, 2019
Vaccine
Publication - Summary
May 17, 2019
Science Immunology
Publication - Summary
Apr 12, 2019
Journal of Controlled Release
Publication - Summary
Feb 07, 2019
Molecular Therapy Nucleic Acids
Publication - Summary
Feb 07, 2019
Nano Research
Publication - Abstract
Dec 18, 2018
Cell Reports
Publication - Abstract
Oct 29, 2018
Nature Communications
Publication - Abstract
Oct 01, 2018
Cellular and Molecular Bioengineering
Publication - Summary
Sep 24, 2018
Nucleic Acid Therapeutics
Publication - Abstract
Jul 24, 2018
RNA Biology
Publication - Abstract
Jun 15, 2018
Molecular therapy
Publication - Abstract
Jun 13, 2018
Journal of Nucleic Acids
Alpha-1-antitrypsin (AAT) deficiency is a genetic disorder that produces inactive/defective AAT due to mutations in the SERPINA1 gene encoding AAT. This disease is associated with decreased activity of AAT in the lungs and deposition of excessive defective AAT protein in the l...
Publication - Abstract
May 25, 2018
Multiple Myeloma
Publication - Abstract
Apr 26, 2018
Small Methods
Lipid nanoparticles (LNPs) are currently the most clinically advanced nonviral carriers for the delivery of small interfering RNA (siRNA). Free siRNA molecules suffer from unfavorable physicochemical characteristics and rapid clearance mechanisms, ...
Publication - Abstract
Mar 27, 2018
PNAS
The development of safe and efficacious gene vectors has limited greatly the potential for therapeutic treatments based on messenger RNA (mRNA). Lipid nanoparticles (LNPs) formed by an ionizable cationic lipid (here DLin-MC3-DMA), helper lipids (di...
Publication - Abstract
Mar 19, 2018
Advanced Drug Delivery Reviews
Lipid-based nanobiomaterials as liposomes and lipid nanoparticles (LNPs) are the most widely used nanocarriers for drug delivery systems (DDSs). Extracellular vesicles (EVs) and exosomes are also expected to be applied as DDS nanocarriers. The perf...
Publication - Summary
Feb 27, 2018
Cell Reports
Hereditary transthryretin amyloidosis is a rare disease caused by mutations in the gene encoding the protein transthyretin (TTR), causing it to misfold into amyloid plaques, leading to debilitating symptoms. In 2018,...
Publication - Abstract
Feb 15, 2018
Vaccine
A cytomegalovirus (CMV) vaccine that is effective at preventing congenital infection and reducing CMV disease in transplant patients remains a high priority as no approved vaccines exist. While the precise correlates of protection are unknown, neut...
Publication - Abstract
Jan 14, 2018
The Journal of Physical Chemistry
Here, we show how dynamic nuclear polarization (DNP) NMR spectroscopy experiments permit the atomic level structural characterization of loaded and empty lipid nanoparticles (LNPs). The LNPs used here were synthesized by the microfluidic mixing tec...
Publication - Abstract
Dec 21, 2017
Journal of Infectious Diseases
Publication - Summary
Dec 19, 2017
Cell Reports
Inborn errors of metabolism (IEMs) can be relatively straight forward to screen for and diagnose; these disorders however, have currently very limited options for treatment. Methylmalonic acidemia (MMA), is an IEM caused by complete or partial defi...
Publication - Abstract
Dec 06, 2017
Molecular Therpay
mRNA vaccines are rapidly emerging as a powerful platform for infectious diseases because they are well tolerated, immunogenic, and scalable and are built on precise but adaptable antigen design. We show that two immunizations of modified non-repli...
Publication - Abstract
Nov 13, 2017
Frontiers in Immunology
Modified mRNA vaccines have developed into an effective and well-tolerated vaccine platform that offers scalable and precise antigen production. Nevertheless, the immunological events leading to strong antibody responses elicited by mRNA vaccines a...
Publication - Summary
Sep 24, 2017
Nano Letters
Gene delivery for the purpose of protein expression has been traditionally performed by electroporation or viral transduction of plasmid DNA. Plasmid delivery has numerous challenges as they could potentially integrate into host genome and require ...
Publication - Abstract
Jul 21, 2017
Methods in Molecular Biology
Lipid-like nanoparticles (LLNs) have shown great promise for nucleic acid delivery. Recently, we have developed N1,N3,N5-tris(2-aminoethyl)benzene-1,3,5-tricarboxamide (TT) derived li...
Publication - Summary
Jul 13, 2017
Cell
Lately there has been intense effort to develop vaccines for Zika virus, in part due to the recently established link between Zika infection and congenital birth defects such as microcephaly and the rapid spread of Zika in Oceania and the Americas ...
Publication - Abstract
Jul 07, 2017
ACS Applied Materials & Interfaces
Efficient and safe delivery of the CRISPR/Cas system is one of the key challenges for genome-editing applications in humans. Herein, we designed and synthesized a series of biodegradable lipidlike compounds containing ester groups for the delivery ...
Publication - Summary
Apr 27, 2017
Molecular Therapy
The swine influenza pandemic of 2009 and more recent zoonotic transmissions of several avian influenza subtypes to human populations punctuates the threat posed by new pathogens for which we have no pre-existing immunity. Traditional vaccines requi...
Publication - Summary
Feb 17, 2017
Cell
In the recent years, Zika virus (ZIKV) infection has become a global health threat. This infection has been known to cause multiple symptoms in adults including myalgia and conjunctivitis. More recent studies have also linked ZIKV with congenital m...
Publication - Summary
Dec 16, 2016
Angewandte Chemie International Edition
The CRISPR/Cas (clustered regularly interspaced short palindromic repeat/CRISPR-associated protein) gene-editing tool allows for sequence-specific cuts to genomic DNA, which can result in permanent silencing of a gene, or replacement of gene sequen...
Publication - Abstract
Dec 15, 2016
Nanoscale
Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance...
Publication - Abstract
Aug 05, 2016
Journal of Drug Targeting
Microfluidic devices are mircoscale fluidic circuits used to manipulate liquids at the nanoliter scale. The ability to control the mixing of fluids and the continuous nature of the process make it apt for solvent/antisolvent precipitation of drug-d...
Publication - Abstract
May 04, 2016
Journal of Drug Targeting
Small interfering RNAs (siRNAs) therapeutics has advanced into clinical trials for liver diseases and solid tumors, but remain a challenge for manipulating leukocytes fate due to lack of specificity and safety issues. Leukocytes ingest pathogens an...
Publication - Abstract
Feb 26, 2016
Scientific Reports
Lipid-like nanoparticles (LLNs) have shown great potential for RNA delivery. Lipid-like compounds are key components in LLNs. In this study, we investigated the effects of local structural transformation of lipid-like compounds on delivery of messe...
Publication - Summary
Feb 17, 2016
Scientific Reports
To date, most neurodegenerative disorders remain difficult to treat since neither traditional pharmaceutical nor surgical interventions have proven effective for these diseases. Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS...
Publication - Summary
Sep 03, 2015
Nano Letters
Although messenger RNA (mRNA) therapeutics are useful for transiently expressing antibodies and proteins, antigen-specific immune responses make the systemic delivery of mRNA challenging.
Publication - Abstract
Apr 09, 2015
Journal of Liposome Research
Previous studies from this group have shown that limit size lipid-based systems—defined as the smallest achievable aggregates compatible with the packing properties of their molecular constituents—can be efficiently produced using a&nbs...
Application Note
Mar 15, 2022
Video
Aug 10, 2017
Derek O’Hagan, Global Head of Vaccine Chemistry and Formulation GSK vaccines Research in Cambridge | 2nd Annual Nanomedicines Symposium, July 15th, 2017
Video
Aug 16, 2017
2nd Annual Nanomedicines Symposium, July 15th, 2017, Cambridge MA | Peter Johnson, Field Application Scientist, PNI
Video
Aug 16, 2017
2nd Annual Nanomedicines Symposium, July 15th, 2017 Cambridge MA
Video
Aug 04, 2017
2nd Annual Nanomedicine Symposium | Ocular Delivery of mRNA - Patrick Baumhof, CureVac AG
Video
Nov 30, 2016
From our 2016 Nanomedicines Symposium in LONDON, UK NOVEMBER 29th, 2016
Video
Aug 10, 2016
NanoAssemblr® Spark™ Tech Talk from 2016 PNI Nanomedicine Symposium
Video
Aug 10, 2016
NanoAssemblr® Benchtop Tech Talk from 2016 Nanomedicine Symposium
Video
Jul 26, 2016
Liposomes: from Prototype to the Clinic | Norbert Maurer, Transferra Nanosciences
Video
Jul 26, 2016
Microfluidics in manufacturing of mRNA Nanomedicines | Heinrich Haas, BioNTech
Video
Jul 25, 2016
Improved CRISPR Genome Editing using crRNA:tracrRNA complexes and Cas9 | Ashley Jacobi, IDT
Video
Jul 26, 2016
Targeted mRNA delivery to the Liver for Intracellular Enzyme Replacement Therapy | Pierrot Harvie, PhaseRX
Video
Dec 15, 2016
Keynote Speaker from our Nanomedicines Symposium November 29th, London UK
Ray Schiffelers - Facing the Challenge of Reproducible and Scalable Nanoparticle Production for RNA Delivery - Keynote
Video
Nov 30, 2016
Nanomedicines Symposium, November 29th, 2016 - LONDON UK
Stephen Hart - Targeted Lipid/Peptide Nanocomplexes for Nucleic Acid Delivery - UCL
Webinar
Jul 21, 2022
Webinar
Nov 17, 2020
Webinar
Jun 27, 2020
Webinar
Apr 24, 2019
Featuring speaker Dr. Yvonne Perrie, this webinar will explore advances in mRNA Vaccine Therapies in the fields of Cancer Immunotherapy and Infectious Diseases.
Dr. Yvonne Perrie
Professor in Drug Delivery, Str...
Webinar
Apr 24, 2019
Featuring speaker Dr. Justin Richner, this livestream will explore advances in mRNA Vaccine Therapies in the fields of Cancer Immunotherapy and Infectious Diseases.
Dr. Justin M. Richner
Assistant Professor, Department of Microbio...
Webinar
Nov 08, 2017
Discover how nanoparticles can deliver vaccines and elicit immune responses and see some of the latest research on mRNA vaccines and immuno-oncology therapeutics. Share this video with others who are interested in the latest in vaccine research.
Webinar
Oct 20, 2016
Webinar from Dr. Gaurav Sahay, Assistant Professor, OSU/OHSU College of Pharmacy
The deployment of nanoparticles that can deliver drugs/genes inside cells by exploiting endocytosis has shown tremendous potential for bi...
Article
Dec 08, 2023
Article
Dec 01, 2023
Article
Nov 01, 2023
Article
Jul 27, 2023
Article
Jun 05, 2023
Article
Dec 07, 2022
Article
Jul 28, 2022
Article
Jun 09, 2022
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