Microfluidic Assembly of Liposomes with Tunable Size and Coloading Capabilities


Authors: JR Hoffman, E Tasciotti, R Molinaro

Journal: Multiple Myeloma

DOI: 10.1007/978-1-4939-7865-6_15

Publication - Abstract

May 25, 2018

Small Molecule Drugs Nucleic Acid Lipid Nanoparticles Oncology
Liposomes used for the delivery of pharmaceuticals have difficulties scaling up and reaching clinical translation as they suffer from batch-to-batch variability. Here, we describe a microfluidic approach for creating reproducible, homogenous nanoparticles with tunable characteristics. These nanoparticles of sizes ranging from 30 to 500 nm are rapidly self-assembled by controlling the flow rates of ethanol and aqueous streams. This method of microfluidic assembly allows for the efficient encapsulation of both hydrophobic and hydrophilic drugs in the lipid bilayer and particle core, respectively, either separately or in combination.

limit search to this category
Advanced Search

Advanced Search

close
  • Publications
  • Application Notes
  • Posters
  • Workshops
  • Videos & Webinars
  • Articles
Search

Browse by Category

  • Application
    • Diagnostic and Imaging
    • Genetic Medicine
    • Hematology
    • Metabolic Disorders
    • Neuroscience
    • Oncology
    • Skeletal Disorders
    • Targeted Drug Delivery
    • Vaccines
    • Other Applications
    • Cell therapy
  • Formulation
    • Liposomes
    • Nucleic Acid Lipid Nanoparticles
    • Polymeric Nanoparticles
    • Other Formulations
  • Payload
    • DNA
    • microRNA
    • mRNA
    • siRNA
    • Small Molecule Drugs
    • Other Payloads


related content

Publication - Summary

Feb 17, 2016
Scientific Reports

Intrathecal Delivery of Frataxin mRNA Encapsulated in Lipid Nanoparticles to Dorsal Root Ganglia as a Potential Therapeutic for Friedreich’s Ataxia

J.F. Nabhan, K.M Wood, V.P. Rao, J. Morin, S. Bhamidipaty, T.P. LaBranche, R.L. Gooch, F. Bozal, C.E. Bulawa and B.C. Guild

mRNA Nucleic Acid Lipid Nanoparticles Neuroscience

To date, most neurodegenerative disorders remain difficult to treat since neither traditional pharmaceutical nor surgical interventions have proven effective for these diseases. Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS...

Read More


Publication - Abstract

May 02, 2020
Processes

Comprehensive Screening of Drug Encapsulation and Co-Encapsulation into Niosomes Produced Using a Microfluidic Device

S. Joshi, R. White, R. Sahu, V.A. Dennis and S.R. Singh

Small Molecule Drugs Other Formulations
Microfluidics is a very facile and fast method of particulate production. Besides, it enables the manufacturing of size tuned particulate systems. Niosomes due to structural similarities have importance as alternative drug delivery systems to liposomes. Niosomes can be encapsulat...
Read More


Sign Up and Stay Informed
Sign up today to automatically receive new Precision NanoSystems application notes, conference posters, relevant science publications, and webinar invites.
Sign Up