Search Results - Resource Center

PUBLICATIONS

Publication - Abstract

Sep 15, 2021
Vaccine

Bacteria Biohybrid Oral Vaccines for Colorectal Cancer Treatment Reduce Tumor Growth and Increase Immune Infiltration

M. Naciute, T. Kiwitt, R.A. Kemp,and S. Hook

Oncology Liposomes Other Payloads

Therapeutic peptide cancer vaccines are known to have limited therapeutic effects due to the low immunogenicity of peptides in its composition. In hopes of increasing this therapeutic window, researchers from the Hook Group at the University of Otago School of Pharmacy published ...
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Publication - Abstract

Aug 11, 2021
Advanced Science

Humanized Biomimetic Nanovesicles for Neuron Targeting

A. Zinger, C. Cvetkovic, M. Sushnitha, T. Naoi, G. Baudo, M. Anderson, A. Shetty, N. Basu, J. Covello, E. Tasciotti, M. Amit, T. Xie, F. Taraballi, and R. Krencik

Other Payloads Small Molecule Drugs mRNA

In an article written by Zinger et al. 2021 from the Center for Musculoskeletal Regeneration at the Houston Methodist Research Institute, the challenge of reproducible and scalable therapeutic drug delivery with high cell specificity to neural cells was investigated through analy...
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Publication - Abstract

Apr 20, 2021
ACS Biomaterials Science & Engineering

Manual Versus Microfluidic-Assisted Nanoparticle Manufacture: Impact of Silk Fibroin Stock on Nanoparticle Characteristics

J.I. Solomun, J.D. Totten, T. Wongpinyochit, A.J. Florence and F.P. Seib

Other Payloads Other Formulations Other Applications

Silk has a long track record of clinical use in the human body, and new formulations, including silk nanoparticles, continue to reveal the promise of this natural biopolymer for healthcare applications. Native silk fibroin can be isolated directly from the silk gland, but generat...
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Publication - Abstract

Mar 16, 2021
ACS Nano

Enhancing Inflammation Targeting Using Tunable Leukocyte-Based Biomimetic Nanoparticles

A. Zinger, M. Sushnitha, T. Naoi, G. Baudo, E. De Rosa, J. Chang, E. Tasciotti and F. Taraballi

Other Payloads Targeted Drug Delivery Other Applications

Biomimetic nanoparticles aim to effectively emulate the behavior of either cells or exosomes. Leukocyte-based biomimetic nanoparticles, for instance, incorporate cell membrane proteins to transfer the natural tropism of leukocytes to the final delivery platform. However, tuning t...
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Publication - Abstract

Feb 16, 2021
Advanced Materials

A Comprehensive Review on Intracellular Delivery

D.M. Rad, M.A. Rad, S.R. Bazaz, N. Kashaninejad, D. Jin and M.E. Warkiani

Other Payloads Other Formulations Other Applications

Intracellular delivery is considered an indispensable process for various studies, ranging from medical applications (cell‐based therapy) to fundamental (genome‐editing) and industrial (biomanufacture) approaches. Conventional macroscale delivery systems critically suffer from su...
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Publication - Abstract

Dec 07, 2020
Journal of Controlled Release

Antigen Folding Improves Loading Efficiency and Antitumor Efficacy of PC7A Nanoparticle Vaccine

J. Wilhelm, M. Quiñones-Pérez, J. Wang, X. Wang, V.S. Basava and J. Gao

Other Payloads Polymeric Nanoparticles Oncology

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Publication - Abstract

Nov 30, 2020
International Journal of Pharmaceutics

Microfluidic Production of Protein Loaded Chimeric Stealth Liposomes

M.T. Hussain, M. Tiboni, Y. Perrie and L. Casettari

Other Payloads Other Applications Liposomes

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Publication - Abstract

Nov 04, 2020
Science Advances

CD8+ T Cells Mediate Protection Against Zika Virus Induced by an NS3-based Vaccine

A.E. Ngono, T. Syed, A.V. Nguyen, J.A. Regla-Nava, M. Susantono, D. Spasova, S. Shresta et. al.

Other Payloads Other Formulations Vaccines

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Publication - Abstract

Nov 02, 2020
Journal of Controlled Release

Rational Design of Adjuvants for Subunit Vaccines: The Format of Cationic Adjuvants Affects the Induction of Antigen-specific Antibody Responses

G. Anderluzzi, S.T. Schmidt, R. Cunliffe, S. Woods, C.W. Roberts, D. Veggi, I. Ferlenghi, D.T. O'Hagan, B.C. Baudner and Y. Perrie

Other Payloads Other Formulations Polymeric Nanoparticles

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Publication - Abstract

Oct 17, 2020
Journal of Controlled Release

Alpha-dystroglycan Binding Peptide A2G80-modified Stealth Liposomes as a Muscle-targeting Carrier for Duchenne Muscular Dystrophy

E. Sasaki, Y. Hayashi, Y. Kimura, S. Sashida, N. Hamano, Y. Negishi et. al.

Other Payloads Liposomes Other Applications

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Publication - Abstract

Oct 06, 2020
ACS Applied Nano Materials

Versatile and High-Throughput Strategy for the Quantification of Proteins Bound to Nanoparticles

R. Oliverio, B. Liberelle, F. Murschel, A. Garcia-Ac, X. Banquy and G. De Crescenzo

Polymeric Nanoparticles Other Applications Other Formulations

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Publication - Abstract

Sep 10, 2020
Drug Delivery Letters

Microfluidic Manufacture of Solid Lipid Nanoparticles: A Case Study on Tristearin-Based Systems

G. Anderluzzi and Y. Perrie

Other Applications Other Payloads Other Formulations

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Publication - Abstract

Sep 01, 2020
International Journal of Pharmaceutics

Microfluidic Preparation of Various Perfluorocarbon Nanodroplets: Characterization and Determination of Acoustic Droplet Vaporization (ADV) Threshold

R. Melich, P. Bussat, L. Morici, A. Vivien, E. Gaud, T. Bettinger and S. Cherkaoui

Other Payloads Other Formulations Other Applications

Over the last two decades, liquid perfluorocarbon nanodroplets (PFC-NDs), also known as Phase Change Contrast Agents (PCCAs), that are capable of vaporizing into gaseous echogenic microbubbles via an external stimulus, have gained much attention for diagnostic and therapeutic app...
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Publication - Abstract

Aug 03, 2020
Vaccines

Lipid Nanoparticle Acts as a Potential Adjuvant for Influenza Split Vaccine without Inducing Inflammatory Responses

S. Shirai, A. Kawai, M. Shibuya, L. Munakata, D. Omata, R. Suzuki and Y. Yoshioka

Other Payloads Vaccines Nucleic Acid Lipid Nanoparticles

In this in vitro and in vitro study, the Yoshioka lab at Osaka University investigated cytosine–phosphate–guanine oligodeoxynucleotides (CpG ODN) lipid nanoparticles (LNPs) as an adjuvant for seasonal split vaccines (SV) from influenza virus antig...
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Publication - Abstract

Jun 22, 2020
Small

Shedding Light on Metal‐Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution

E. Cörek, G. Rodgers, S. Siegrist, T. Einfalt, P. Detampel, C.M. Schlepütz, S. Sieber, P. Fluder, G. Schulz, H. Unterweger, C. Alexiou, B. Müller, M. Puchkov and J. Huwyler

Other Formulations Other Payloads Other Applications

Metal‐based nanoparticles are clinically used for diagnostic and therapeutic applications. After parenteral administration, they will distribute throughout different organs. Quantification of their distribution within tissues in the 3D space, however, remains a challenge owing to...
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Publication - Abstract

Jun 15, 2020
Journal of Colloid and Interface Science

Microfluidic-directed Self-assembly of Liposomes: Role of Interdigitation

S.W.Z. Lim, Y.S. Wong, B. Czarny and S. Venkatraman

Liposomes Other Payloads Other Applications

Microfluidics has been used to process self-assembling liposomal systems that are commonly considered for drug delivery applications. However, it has been found that the parameters of the process are not universally suited for all lipid types. We hypothesize here that size aggreg...
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Publication - Abstract

Jun 05, 2020
Journal of Controlled Release

Glucosamine-NISV Delivers Antibody Across the Blood-brain Barrier: Optimization for Treatment of Encephalitic Viruses

S. Woods, L.M. O'Brien, W. Butcher, J.E. Preston, A.R. Georgian, E.D. Williamson, F.J. Salguero, F. Modino, N.J. Abbott, C.W. Roberts and R.V. D'Elia

Other Formulations Other Payloads Vaccines

The field of brain drug delivery faces many challenges that hinder development and testing of novel therapies for clinically important central nervous system disorders. Chief among them is how to deliver large biologics across the highly restrictive blood-brain barrier. Non-ionic...
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Publication - Abstract

Jun 01, 2020
MethodsX

Synthesis of Protein Conjugates Adsorbed on Cationic Liposomes Surface

D. Chatzikleanthous, R. Cunliffe, F. Carboni, M.R. Romano, D.T. O'Hagan, C.W. Roberts, Y. Perrie and R. Adamo

Vaccines Other Payloads Liposomes

The well-known Toll like receptor 9 (TLR9) agonist CpG ODN has shown promising results as vaccine adjuvant in preclinical and clinical studies, however its in vivo stability and potential systemic toxicity remain a concern. In an effort to overcome these issues...
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Publication - Abstract

May 28, 2020
Journal of Liposome Research

Examination of the Effect of Niosome Preparation Methods in Encapsulating Model Antigens on the Vesicle Characteristics and Their Ability to Induce Immune Responses

M.A. Obeid, T. Teeravatcharoenchai, D. Connell, K. Niwasabutra, M. Hussain, K. Carter and V.A. Ferro

Vaccines Other Formulations Other Payloads

Niosome nanoparticles can be prepared using different methods, each of which can affect the size and homogeneity of the prepared particles. The aim of this study was to establish if the method of preparation impacted on the prepared vesicles when loaded with a model protein and t...
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Publication - Abstract

May 04, 2020
European Journal of Pharmaceutics and Biopharmaceutics

Lipid-encapsulated Oral Therapeutic Peptide Vaccines Reduce Tumour Growth in an Orthotopic Mouse Model of Colorectal Cancer

M. Naciute, V. Niemi, R.A. Kemp and S. Hook

Other Payloads Liposomes Oncology

The aim of this study was to develop an oral vaccine that could be used to treat colorectal cancer. Oral vaccines are technically challenging to develop due to the harsh gastric environment but have numerous benefits including high patient acceptability and the potential to stimu...
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Publication - Abstract

Apr 03, 2020
International Journal of Pharmaceutics

Using Microfluidics for Scalable Manufacturing of Nanomedicines from Bench to GMP: A Case Study Using Protein-loaded Liposomes

C. Webb, N. Forbes, C.B. Roces, G. Anderluzzi, G. Lou, S. Abraham, L. Ingalls, K. Marshall, T.J. Leaver, J.A. Watts, J.W. Aylott, and Y. Perrie

Other Payloads Liposomes

In a 2020 study conducted by researchers at the University of Strathclyde Institute of Pharmacy and Biomedical Sciences, a scale-by-scale development of genetic medicines from bench to GMP was outlined through the generation of liposomes with a protein payload using two different...
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Publication - Abstract

Apr 02, 2020
Journal of Controlled Release

Design of a Novel Vaccine Nanotechnology-based Delivery System Comprising CpGODN-protein Conjugate Anchored to Liposomes

D. Chatzikleanthous, S.T. Schmidt, G. Buffi, I. Paciello, R. Cunliffe, F. Carboni, M.R. Romano, D.T. O'Hagan, U. D'Oro, S. Woods, C.W. Roberts, Y. Perrie, and R. Adamo

DNA Liposomes Vaccines

Although the well-known Toll like receptor 9 agonist CpGODN has shown promising results as vaccine adjuvant in preclinical and clinical studies, its in vivo stability and potential systemic toxicity remain a concern. In an effort to circumvent these issues, different strategies h...
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Publication - Abstract

Feb 10, 2020
Drug Delivery and Translational Research

Technological Challenges in the Preclinical Development of an HIV Nanovaccine Candidate

T.G. Dacoba, L. Ruiz-Gatón, A. Benito. M. Klein, D. Dupin, M. Luo, M. Menta, D. Teijeiro-Osorio, I. Loinaz, M.J. Alonso and J. Crecente-Campo

Polymeric Nanoparticles Other Payloads Vaccines

Despite a very active research in the field of nanomedicine, only a few nano-based drug delivery systems have reached the market. The “death valley” between research and commercialization has been partially attributed to the limited characterization and reproducibilit...
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Publication - Abstract

Jan 24, 2020
Plos One

Microfluidic-prepared DOTAP Nanoparticles Induce Strong T-cell Responses in Mice

Y. Haseda, L. Munakata, J. Meng, R. Suzuki, and T. Aoshi

DNA Liposomes Other Payloads

For the induction of antigen-specific T-cell responses by vaccination, an appropriate immune adjuvant is required. Vaccine adjuvants generally provide two functions, namely, immune potentiator and delivery, and many adjuvants that can efficiently induce T-cell responses are known...
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Publication - Abstract

Jan 09, 2020
Drug Delivery and Translational Research

Translating the Fabrication of Protein-loaded Poly(lactic-co-glycolic acid) Nanoparticles from Bench to Scale-independent Production Using Microfluidics

C.B. Roces, D. Christensen and Y. Perrie

Other Payloads Vaccines Polymeric Nanoparticles

In the formulation of nanoparticles, poly(lactic-co-glycolic acid) (PLGA) is commonly employed due to its Food and Drug Administration and European Medicines Agency approval for human use, its ability to encapsulate a variety of moieties, its biocompatibility and biodegradability...
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Publication - Abstract

Dec 31, 2019
Vaccines

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

C.B. Roces, M.T. Hussain, S.T. Schmidt, D. Christensen and Y. Perrie

Other Payloads Polymeric Nanoparticles Vaccines

Scientists from the Institute of Pharmacy and Biomedical Science at the University of Strathclyde confirm the ability of PLGA polymeric nanoparticles in a dry powder form to successfully deliver an encapsulated antigen payload intranasally for uptake in cells residing in the deep...
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Publication - Abstract

Nov 28, 2019
Journal of Controlled Release

Optimizing Biodegradable Nanoparticle Size for Tissue-specific Delivery

H.K. Mandl, E. Quijano, H.W. Suh, E. Sparago, S. Oeck, M. Grun, P.M. Glazer, and W.M. Saltzman

Polymeric Nanoparticles Other Payloads Other Applications

Nanoparticles (NPs) are promising vehicles for drug delivery because of their potential to target specific tissues [1]. Although it is known that NP size plays a critical role in determining their biological activity, there are few quantitative studies of the role of NP size in d...
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Publication - Abstract

Oct 24, 2019
Circulation Research

Rapamycin-Loaded Biomimetic Nanoparticles Reverse Vascular Inflammation

C. Boada, A. Zinger, C. Tsao, P. Zhao, J.O. Martinez, K. Hartman, T. Naoi, R. Sukhoveshin, M. Sushnitha, R. Molinaro, B. Trachtenberg, J.P. Cooke, and E. Tasciotti

Other Formulations Other Payloads Other Applications

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Publication - Abstract

Sep 01, 2019
Journal of Colloid and Interface Science

The Distribution of Cell-penetrating Peptides on Polymeric Nanoparticles Prepared Using Microfluidics and Elucidated with Small Angle X-ray Scattering

S. Streck, A.J. Clulow, H.M. Nielsen, T. Rades, B.J. Boyd, and A. McDowell

Other Payloads Polymeric Nanoparticles Other Applications

Hypothesis:
The distribution of three cell-penetrating peptides (CPPs) with different architectures (short, long linear and branched) on poly(lactic-co-glycolic) acid (PLGA) nanoparticles depends on the conjugation approach. Here, we explore the utilization of a zero-length...
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Publication - Abstract

Aug 22, 2019
Drug Delivery Systems

Construction of a Macrophage-Targeting Bio-nanocapsule-Based Nanocarrier

H. Li, M. Somiya, K. Tatematsu, and S. Kuroda

Other Applications Liposomes Other Payloads

The construction protocol of bio-nanocapsule (BNC)-based nanocarriers, named GL-BNC and GL-virosome, for targeted drug delivery to macrophages is described here. First, genes encoding the Streptococcus sp. protein G-derived C2 domain (binds to IgG Fc) and Finegoldia magna ...
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Publication - Abstract

Aug 19, 2019
Molecular Pharmaceutics

Scale-Independent Microfluidic Production of Cationic Liposomal Adjuvants and Development of Enhanced Lymphatic Targeting Strategies

C.B. Roces, S. Khadke, D. Christensen and Y. Perrie

Other Payloads Liposomes Vaccines

Cationic liposomes prepared from dimethyldioctadecylammonium bromide (DDAB) and trehalose 6,6′-dibehenate (TDB) are strong liposomal adjuvants. As with many liposome formulations, within the laboratory DDAB:TDB is commonly prepared by the thin-film method, which is difficul...
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Publication - Abstract

Jul 31, 2019
European Journal of Biotechnology and Bioscience

Formulation and Optimization of Biodegradable Insulin Loaded Nanoparticles

A.G. Eid, N. Uddin, and S. Girgis

Polymeric Nanoparticles Other Payloads

This research aims to provide the diabetic patients with more adequate treatment by designing controlled release insulin loaded nanoparticles prepared by biodegradable polymers. Factors to be studied in this research are the effect of the preparation methods using two different p...
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Publication - Abstract

Jul 09, 2019
Oncogene

Identifying and Targeting Angiogenesis-related microRNAs in Ovarian Cancer

X. Chen, L.S. Mangala, L. Mooberry, E. Bayraktar, S.K. Dasari, S. Ma, C. Ivan, K.A. Court, C. Rodriguez-Aguayo, R. Bayraktar, S. Raut, N. Sabnis, X. Kong, X. yang, G. Lopez-Berestein, A.G. Lacko, and A. K. Sood

Liposomes Other Payloads Oncology

Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional approaches are needed. Deregulation of microRNAs (miRNAs) has been demon...
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Publication - Abstract

Jun 19, 2019
Dalton Transactions

Metallosomes for Biomedical Applications by Mixing Molybdenum Carbonyl Metallosurfactants and Phospholipids

M. Marín-García, N. Benseny-Cases, M. Camacho, Y. Perrie, J. Suades and R. Barnadas-Rodríguez

Other Payloads Liposomes Other Applications

New supramolecular systems have been prepared by mixing molybdenum organometallic metallosurfactants M(CO)₅L and M(CO)₄L₂ {L = Ph2P(CH₂)₆<...
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Publication - Abstract

Jun 17, 2019
Lab on a Chip

The Biomolecular Corona of Gold Nanoparticles in a Controlled Microfluidic Environment

L. Digiacomo, S. Palchetti, F. Giulimondi, D. Pozzi, R.Z. Chiozzi, A.L. Capriotti, A. Laganà, and G. Caracciolo

Other Applications Other Formulations Other Payloads

Nanoparticles (NPs) exposed to biological media are coated by proteins and other biomolecules forming a biomolecular corona (BC) on the particle surface. Recent studies have shown that shear stress as that created by laminar fluid flow generates more complex coronas with systemat...

Publication - Abstract

Jun 03, 2019
Journal of Controlled Release

Formulation and Manufacturing of Lymphatic Targeting Liposomes Using Microfluidics

S. Khakde, C.B. Roces, A. Cameron, A Devit and Y. Perrie

Oncology Vaccines Liposomes

The lymphatics are a target for a range of therapeutic purposes, including cancer therapy and vaccination and both vesicle size and charge have been considered as factors controlling lymphatic targeting. Within this work, a range...

Publication - Abstract

Apr 03, 2019
British Journal of Pharmacy

A Novel Biodegradable System Based on Poly(lactic-co-glycolic acid) Nanoparticles for Delivery of a Novel Anticancer Peptide

A.M. Faheem, A.A. Elkordy, M. ElTanani, and S.M. Girgis

Oncology Polymeric Nanoparticles Other Payloads

The main objective of this work was to formulate novel amphiphilic PLGA nanoparticles with improved physicochemical properties for the delivery of the novel peptide (CK-10) to be used for targeting of the cancerous/tumour tissue. This was achieved by blending of various amphiphil...

Publication - Abstract

Jan 29, 2019
Pharmaceutics

Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

X. Ge, M. Wei, S. He and W-E. Yuan

Small Molecule Drugs Other Formulations Other Payloads

Non-Ionic surfactant based vesicles, also known as niosomes, have attracted much attention in pharmaceutical fields due to their excellent behavior in encapsulating both hydrophilic and hydrophobic agents. In recent years, it has been discovered that these vesicles can improve th...

Publication - Abstract

Nov 29, 2018
Carbohydrate Polymers

N-oxy Lipid-based Click Chemistry for Orthogonal Coupling of Mannan onto Nanoliposomes Prepared by Microfluidic Mixing...

E. Bartheldyová, P.T. Knotigová, K. Zachová and J. Turánek et al.

Vaccines Liposomes Other Payloads

New synthetic aminooxy lipid was designed and synthesized as a building block for the formulation of functionalised nanoliposomes (presenting onto the outer surface of aminooxy groups) by microfluidic mixing. Orthogonal binding of cellular mannan (Candida glabrata (CCY 26-20-1) o...

Publication - Abstract

Nov 29, 2018
International Journal of Pharmaceutics

Rapid and Scale-independent Microfluidic Manufacture of Liposomes Entrapping Protein Incorporating In-line Purification and At-line Size Monitoring

N. Forbes, MT. Hussain, ML. Briuglia, DY. Edwards, JH. terHorst, N. Szita, Y. Perrie

Other Payloads Other Applications Liposomes

Within this paper we present work that has the ability to de-risk the translation of liposomes from bench to the clinic. We have used microfluidics for the rapid and scale-independent manufacture of liposomes and have incorporated in-line purification and at-line monitoring of pa...

Publication - Abstract

Mar 07, 2018
Advanced Material

Design and Development of Biomimetic Nanovesicles Using a Microfluidic Approach

R. Molinaro, M. Evangelopoulos, J. Hoffman, C. Corbo, F. Taraballi, J. Martinez, Kelly. Hartman, D. Cosco, G. Costa, I. Romeo, M. Sherman, D. Paolino ,S. Alcaro and E. Tasciotti

Other Payloads Other Applications Liposomes

The advancement of nanotechnology toward more sophisticated bioinspired approaches has highlighted the gap between the advantages of biomimetic and biohybrid platforms and the availability of manufacturing processes to scale up their production. Th...

Publication - Summary

Feb 27, 2018
Cell Reports

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

J. Finn, A. Smith, M. Patel, L. Shaw, M. Youniss, J. Heteren, T. Dirstine, C. Ciullo, R. Lescarbeau, J. Seitzer, R. Shah, A. Shah, D. Ling, J. Growe, M. Pink, E. Rohde, K. Wood, W. Salomon, W. Harrington, C. Dombrowski, W. Strapps, Y. Chang, D. Morrissey

Other Payloads mRNA Nucleic Acid Lipid Nanoparticles

Hereditary transthryretin amyloidosis is a rare disease caused by mutations in the gene encoding the protein transthyretin (TTR), causing it to misfold into amyloid plaques, leading to debilitating symptoms. In 2018,...

Publication - Abstract

Jan 08, 2018
Scientific Reports

High Content Image Analysis Reveals Function of miR-124 Upstream of Vimentin in Regulating Motor Neuron Mitochondria

T. Yardeni, R. Fine, Y. Joshi, T. Gradus-Pery, N. Kozer, I. Reichenstein, E. Yanowski, S. Nevo, H. Weiss-Tishler, M. Eisenberg-Bord, T. Shalit, A. Plotnikov, H.M. Barr, E. Perlson and E. Hornstein

Other Payloads microRNA Nucleic Acid Lipid Nanoparticles

microRNAs (miRNAs) are critical for neuronal function and their dysregulation is repeatedly observed in neurodegenerative diseases. Here, we implemented high content image analysis for investigating the impact of several miRNAs in mouse primary mot...

Publication - Summary

Sep 01, 2017
Scientific Reports

Formation and Purification of Tailored Liposomes for Drug Delivery Using a Module-Based Micro Continuous-Flow System

N. Dimov, E. Kastner, M. Hussain, Y. Perrie and N. Szita

Small Molecule Drugs Other Payloads Other Applications

Currently, clinically approved medicines with liposomal formulations have a combined annual revenue of approximately $100 million USD, but their difficult and expensive production methods make more widespread use prohibitive. Microfluidic devi...

Publication - Summary

Dec 16, 2016
Angewandte Chemie International Edition

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

Miller JB, Zhang S, Kos P, Xiong H, Zhou K, Perelman SS, Zhu H, Siegwart DJ

Other Payloads mRNA Nucleic Acid Lipid Nanoparticles

The CRISPR/Cas (clustered regularly interspaced short palindromic repeat/CRISPR-associated protein) gene-editing tool allows for sequence-specific cuts to genomic DNA, which can result in permanent silencing of a gene, or replacement of gene sequen...

Publication - Abstract

Apr 01, 2016
Advanced Drug Delivery Reviews

Designing Liposomal Adjuvants for the Next Generation of Vaccines

Y. Perrie, F. Crofts, A. Devitt, H. Griffiths, E. Kastner and V. Nadella

Other Payloads Vaccines Liposomes

Liposomes not only offer the ability to enhance drug delivery, but can effectively act as vaccine delivery systems and adjuvants. Their flexibility in size, charge, bilayer rigidity and composition allow for targeted antigen delivery via ...