Publication - Abstract
Jan 28, 2021
Vaccines
Publication - Abstract
Jan 22, 2021
ACS Nano
Publication - Abstract
Dec 21, 2020
Molecular Therapy
Abstract
Self-amplifying RNA (saRNA) is a cutting-edge platform for both nucleic acid vaccines and therapeutics. saRNA is self-adjuvanting, as it activates types I and III interferon (IFN), which enhances the immunogenicity of RNA vaccines but can also lead to inhibition...Publication - Abstract
Dec 16, 2020
pharmaceutics
Publication - Abstract
Dec 07, 2020
Journal of Controlled Release
Publication - Abstract
Dec 03, 2020
Journal of Medical Virology
Publication - Abstract
Nov 26, 2020
Journal of Controlled Release
mRNA was formulated in lipoplexes with ionizable, cationic or zwitterionic complexing lipids.
Cell populations in human skin were analyzed for RNA uptake and expression over 72 h.
Adipocytes exhibit...
Publication - Abstract
Nov 09, 2020
pharmaceutics
Publication - Abstract
Nov 04, 2020
Science Advances
Publication - Abstract
Nov 02, 2020
Journal of Controlled Release
Publication - Abstract
Aug 25, 2020
ACS Applied Nano Materials
Publication - Abstract
Aug 11, 2020
Journal of Controlled Release
siRNA and mRNA structures were separated from the ChriST mRNA by RNase H-mediated cleavage of RNA/DNA ...
Publication - Abstract
Aug 03, 2020
Vaccines
In this in vitro and in vitro study, the Yoshioka lab at Osaka University investigated cytosine–phosphate–guanine oligodeoxynucleotides (CpG ODN) lipid nanoparticles (LNPs) as an adjuvant for seasonal split vaccines (SV) from influenza virus antig...
Publication - Abstract
Jul 08, 2020
Advanced Drug Delivery Reviews
Publication - Abstract
Jul 03, 2020
Journal of Medical Virology
Publication - Abstract
Jul 01, 2020
Journal of Controlled Release
Publication - Abstract
Jun 05, 2020
Journal of Controlled Release
Publication - Abstract
Jun 01, 2020
MethodsX
Publication - Abstract
May 29, 2020
Scientific Reports
Publication - Abstract
May 28, 2020
Journal of Liposome Research
Publication - Abstract
May 08, 2020
Vaccines
Publication - Abstract
May 04, 2020
European Journal of Pharmaceutics and Biopharmaceutics
Publication - Abstract
Apr 02, 2020
Journal of Controlled Release
Publication - Abstract
Feb 10, 2020
Drug Delivery and Translational Research
Publication - Abstract
Feb 04, 2020
npj Vaccines
Publication - Abstract
Jan 09, 2020
Drug Delivery and Translational Research
Publication - Abstract
Dec 31, 2019
Vaccines
Publication - Abstract
Aug 19, 2019
Molecular Pharmaceutics
Publication - Abstract
Jun 03, 2019
Journal of Controlled Release
The lymphatics are a target for a range of therapeutic purposes, including cancer therapy and vaccination and both vesicle size and charge have been considered as factors controlling lymphatic targeting. Within this work, a range...
Publication - Abstract
May 31, 2019
Vaccine
Publication - Summary
May 17, 2019
Science Immunology
Publication - Summary
Feb 07, 2019
Molecular Therapy Nucleic Acids
Publication - Abstract
Dec 18, 2018
Cell Reports
Publication - Abstract
Nov 29, 2018
Carbohydrate Polymers
Publication - Abstract
Jun 13, 2018
Bioconjugate Chemistry
Publication - Abstract
Feb 15, 2018
Vaccine
A cytomegalovirus (CMV) vaccine that is effective at preventing congenital infection and reducing CMV disease in transplant patients remains a high priority as no approved vaccines exist. While the precise correlates of protection are unknown, neut...
Publication - Abstract
Dec 21, 2017
Journal of Infectious Diseases
Publication - Abstract
Dec 06, 2017
Molecular Therpay
mRNA vaccines are rapidly emerging as a powerful platform for infectious diseases because they are well tolerated, immunogenic, and scalable and are built on precise but adaptable antigen design. We show that two immunizations of modified non-repli...
Publication - Abstract
Nov 13, 2017
Frontiers in Immunology
Modified mRNA vaccines have developed into an effective and well-tolerated vaccine platform that offers scalable and precise antigen production. Nevertheless, the immunological events leading to strong antibody responses elicited by mRNA vaccines a...
Publication - Summary
Jul 13, 2017
Cell
Lately there has been intense effort to develop vaccines for Zika virus, in part due to the recently established link between Zika infection and congenital birth defects such as microcephaly and the rapid spread of Zika in Oceania and the Americas ...
Publication - Summary
Apr 27, 2017
Molecular Therapy
The swine influenza pandemic of 2009 and more recent zoonotic transmissions of several avian influenza subtypes to human populations punctuates the threat posed by new pathogens for which we have no pre-existing immunity. Traditional vaccines requi...
Publication - Summary
Feb 17, 2017
Cell
In the recent years, Zika virus (ZIKV) infection has become a global health threat. This infection has been known to cause multiple symptoms in adults including myalgia and conjunctivitis. More recent studies have also linked ZIKV with congenital m...
Publication - Abstract
Oct 08, 2016
Vaccine Adjuvants
A wide range of studies have shown that liposomes can act as suitable adjuvants for a range of vaccine antigens. Properties such as their amphiphilic character and biphasic nature allow them to incorporate antigens within the lipid bilayer, on the ...
Publication - Abstract
Apr 01, 2016
Advanced Drug Delivery Reviews
Liposomes not only offer the ability to enhance drug delivery, but can effectively act as vaccine delivery systems and adjuvants. Their flexibility in size, charge, bilayer rigidity and composition allow for targeted antigen delivery via ...
APPLICATION NOTES
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Application Note
Mar 15, 2022
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POSTERS
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VIDEOS & WEBINARS
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Video
Aug 10, 2017
Derek O’Hagan, Global Head of Vaccine Chemistry and Formulation GSK vaccines Research in Cambridge | 2nd Annual Nanomedicines Symposium, July 15th, 2017
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Video
Nov 30, 2016
From our 2016 Nanomedicines Symposium in LONDON, UK NOVEMBER 29th, 2016
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Video
Jul 26, 2016
Microfluidics in manufacturing of mRNA Nanomedicines | Heinrich Haas, BioNTech
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Video
Nov 30, 2016
Nanomedicines Symposium
Jaroslav Turanek - Veterinary Research Institute, Brno Czech Republic - -
Video
Nov 30, 2016
Nanomedicines Symposium, London UK November 29th, 2016
Yvonne Perrie, Strathclyde University - Lab-on-Bench Production of Vaccine Adjuvants -
Webinar
Nov 17, 2020
Nobel Prize Laureate Dr. Michael Houghton gives closing remarks on the 2020 Genetic Medicine Evolution Revolution Summit hosted by Precision Nanosystems. He covers the new vaccine landscape after COVID-19 and the impact of RNA vaccines. -
Webinar
Nov 08, 2017
Discover how nanoparticles can deliver vaccines and elicit immune responses and see some of the latest research on mRNA vaccines and immuno-oncology therapeutics. Share this video with others who are interested in the latest in vaccine research.
ARTICLES
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Article
Dec 01, 2023
Analytics and bioassays monitor variables like RNA, LNP composition, polydispersity, particle size, and manufacturing process to accelerate RNA-LNP production.Read More -
Article
Nov 01, 2023
Outsourcing RNA–LNP drug manufacturing accelerates drug development with advanced cGMP technologies, comprehensive analytical testing, and biopharma services.Read More -
Article
Jul 27, 2023
Single-use technology provides a sterile environment, accelerating biopharmaceutical manufacturing of mRNA-LNP drugs with less cleaning and validation needs.Read More -
Article
Dec 07, 2022
Limit size behavior, in-line dilution and tangential flow filtration are important process considerations to evaluate and optimize during process development.Read More -
Article
Jul 28, 2022
RNA vaccines are hugely versatile. They can potentially inoculate against any pathogen for which a protein target is known, for example, influenza, chlamydia, HIV-1 (human immunodeficiency virus 1), Ebola and RSV (respiratory syncytial virus). Self-amplifying RNA (saRNA) is a typ...Read More -
Article
Jun 09, 2022
Scale-up and downstream processing operations can impact the functionality and stability of mRNA-LNPs in vaccine development including COVID-19 vaccines.Read More -
Article
Mar 01, 2022
Precision NanoSystems maintains that mRNA and LNP technologies, microfluidics, and distributed manufacturing will revamp vaccine production.Read More -
Article
Mar 01, 2022
During development of pharmaceutically-applicable mRNA therapeutics, synthesis, optimization, and formulation must be taken into consideration.Read More
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